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. 2020 Jul 16;5(4):1113–1126. doi: 10.1016/j.bioactmat.2020.07.002

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© 2020 [The Author/The Authors]

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — DPSC-Exo/CS downregulate the chemotaxis pathway, inflammatory response and immune response in P mice. (A) Heatmap of DEGs in the periodontium of DPSC-Exo/CS-treated group versus the periodontium of CS-treated group (n = 3 per group). (B) Volcano plots showing DEGs. (C) Pie chart showing the number of dysregulated genes. (D) Gene Ontology (GO) functional analysis of the top 200 deregulated genes in the periodontium of the DPSC-Exo/CS-treated group compared with the CS-treated group. (E) Heatmaps of DEGs from the chemotaxis pathway in the periodontium of the DPSC-Exo/CS-treated group compared with the CS-treated group. (F) Heatmaps of DEGs from the inflammatory response pathway in the periodontium of the DPSC-Exo/CS-treated group compared with the CS-treated group. (G) Heatmaps of DEGs from the immune response pathway in the periodontium of the DPSC-Exo/CS-treated group compared with the CS-treated group.