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. 2020 Jul 16;5(4):1113–1126. doi: 10.1016/j.bioactmat.2020.07.002

Fig. 6.

Fig. 6

DPSC-Exo/CS facilitates macrophages to convert from a pro-inflammatory phenotype to an anti-inflammatory phenotype in vitro. (A) Representative IF images of exosome internalization from BMDMs co-cultured with DPSC-Exo/CS and CS. Nuclei were stained with DAPI. Scale bar = 100 μm. (B) Representative density plots of exosome internalization from BMDMs co-cultured with DPSC-Exo/CS (red line) and CS (blue line). (C) Representative density plots of phenotypic characterization of BMDMs co-cultured with DPSC-Exo/CS and CS (n = 6 per group). Gates captured single, live CD11b+F4/80+ cells. (D) Statistical analysis of the flow cytometry data describing the MFI of CD206, Arg, CD86, and iNOS cells with the FMO control in the CD11b+F4/80+ cell population of BMDMs co-cultured with DPSC-Exo/CS and CS (n = 6 per group). Error bar represents SEM. *p < 0.05. (E) The mRNA expression levels of various cytokines and chemokines in BMDMs co-cultured with DPSC-Exo/CS and CS were analysed by RT-qPCR (n = 6 per group). *p < 0.05.