Table 2. Univariate and Multivariate Cox Regression Analyses Predicting Coronary Heart Events with FRS, CACS, and CCTA Variables.
| Variable | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| FRS | ||||||
| Low | 1 | (Ref) | < 0.001* | |||
| Intermediate | 4.1 | 2.2–7.7 | < 0.001* | |||
| High | 4.9 | 2.5–9.3 | < 0.001* | |||
| CACS | ||||||
| 0 | 1 | (Ref) | < 0.001* | 1 | (Ref) | < 0.001* |
| 0.1–100 | 3.5 | 1.7–7.2 | 0.001* | 3.0 | 1.5–6.3 | 0.003* |
| 100.1–400 | 5.0 | 2.4–10.5 | < 0.001* | 3.6 | 1.7–7.7 | 0.001* |
| > 400 | 10.3 | 5.2–20.6 | < 0.001* | 7.1 | 3.4–14.7 | < 0.001* |
| CCTA | ||||||
| Stenosis degree | ||||||
| None | 1 | (Ref) | < 0.001* | 1 | (Ref) | < 0.001* |
| 1–49% | 17.2 | 2.3–127.4 | 0.005* | 14.9 | 2.0–110.9 | 0.008* |
| 50–69% | 60.2 | 8.2–442.0 | < 0.001* | 45.9 | 6.2–342.0 | < 0.001* |
| ≥ 70% | 150.6 | 20.8–1089.4 | < 0.001* | 113.2 | 15.4–834.6 | < 0.001* |
| Plaque type | ||||||
| No plaque | 1 | (Ref) | < 0.001* | 1 | (Ref) | < 0.001* |
| Calcified plaque | 23.3 | 3.1–174.6 | 0.002* | 17.5 | 2.3–131.8 | 0.001* |
| Mixed plaque | 39.1 | 5.3–286.7 | < 0.001* | 26.2 | 3.5–194.2 | 0.001* |
| Non-calcified plaque | 74.5 | 10.2–544.1 | < 0.001* | 53.8 | 7.3–396.3 | < 0.001* |
| High-risk plaque | 125.4 | 16.9–927.5 | < 0.001* | 80.3 | 10.7–601.9 | < 0.001* |
Multivariate analysis was calculated after adjustment of FRS including baseline clinical risk factors. *p < 0.05. CI = confidence interval, HR = hazard ratio, Ref = reference