Table 3. Comparative Results of Qualitative and Quantitative Analyses between cDWI800, sDWI1000, sDWI1500, and cDWI1500.
Parameters | cDWI800 | sDWI1000 | sDWI1500 | cDWI1500 | P | P* | P† | P‡ | P§ |
---|---|---|---|---|---|---|---|---|---|
Suppression of normal glandular tissue | 2.34 ± 0.79 | 2.66 ± 0.78 | 3.32 ± 0.90 | 3.66 ± 0.78 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Overall image quality | 3.31 ± 0.88 | 3.33 ± 0.84 | 3.35 ± 0.81 | 3.73 ± 0.62 | < 0.001 | > 0.999 | 0.002 | > 0.999 | 0.002 |
Lesion conspicuity | 2.83 ± 0.96 | 3.09 ± 0.94 | 3.52 ± 0.92 | 3.39 ± 0.90 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | 0.051 |
CDR (invasive and in situ cancer), % | 84.0 (42/50) | 86.0 (43/50) | 90.0 (45/50) | 90.0 (45/50) | 0.061 | ||||
CDR (invasive cancer), % | 89.7 (35/39) | 92.3 (36/39) | 94.9 (37/39) | 94.9 (37/39) | 0.194 | ||||
Cancer-to-parenchyma contrast ratio | 0.47 ± 0.17 | 0.54 ± 0.16 | 0.63 ± 0.17 | 0.55 ± 0.18 | < 0.001 | < 0.001 | 0.009 | 0.004 | 0.961 |
Pooled data from two readers are mean ± standard deviation. P values were calculated using Friedman test for qualitative anlaysis, Cochran's Q Test for CDR, and one-way ANOVA for cancer-to-parenchyma contrast ratio. *p values indicate comparisons between cDWI800 and sDWI1500 in post-hoc analysis, †p values indicate comparisons between cDWI800 and cDWI1500 in post-hoc analysis, ‡p values indicate comparisons between sDWI1000 and sDWI1500 in post-hoc analysis, §p values indicate comparisons between sDWI1000 and cDWI1500 in post-hoc analysis. CDR = cancer detection rate, cDWI800 = conventional low b-value (800 s/mm2) diffusion-weighted imaging, cDWI1500 = conventional high b-value (1500 s/mm2) diffusion-weighted imaging, sDWI1000 = synthetic high b-value (1000 s/mm2) diffusion-weighted imaging, sDWI1500 = synthetic high b-value (1500 s/mm2) diffusion-weighted imaging