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. 2020 Jul 20;10:12004. doi: 10.1038/s41598-020-68703-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of inhibitory rates (IRs) of single and combination drug regimens. (A) The patient's tissue was excised, divided into fragments, and placed in culture medium, treated with drugs and tested with the MTT assay. Cell viability with various drugs was determined in the HDRA. (B) Example HDRA results from patient 27. (C) Comparison of IR average values for each drug regimen. (D) Comparison of IRs between single drug and combination regimens (Kruskal–Wallis test, *** p < 0.001). (E) The number of drug combinations with the highest IR among the cases tested in the HDRA. Compared to other regimens, GEM/DTAX was excluded due to the small number of assays. (F) Summary of the highest IR values for each patient. Results from patients 7 to 52 with combination regimens.