Table 2.
Inhibitory rate in the histoculture drug response assay (HDRA).
| No | Inhibitory rate (%) of drugs | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Single regimens | Combination regimens | Avg | ||||||||||||||||||
| CD DP |
OXA | IRN | DOX | PTX | DT AX |
EP | BEL | 5FU | GEM | FOx | FOxIri | FBe | FBeOx | GBe | GT | GC | GD | TsOxIri | ||
| 5FU OXA |
5FU OXA IRN |
5FU BEL |
5FU BEL OXA |
GEM BEL |
GEM PTX |
GEM CDDP |
GEM DTAX |
TS-1 OXA IRN |
||||||||||||
| 1 | 27.8 | 46.9 | 10.8 | 37.2 | 22.9 | 22.9 | 7.4 | 16.0 | 29.1 | 24.6 | ||||||||||
| 2 | 10.2 | 65.5 | 10.4 | 41.8 | 4.3 | 74.6 | 4.5 | 4.5 | 52.1 | 29.8 | ||||||||||
| 3 | 21.5 | 41.3 | 2.8 | 44.4 | 8.9 | 3.0 | 7.0 | 10.7 | 5.3 | 16.1 | ||||||||||
| 4 | 45.3 | 19.9 | 43.5 | 22.4 | 6.1 | 4.9 | 42.1 | 28.4 | 12.6 | 25.0 | ||||||||||
| 5 | 28.2 | 3.3 | 2.4 | 18.2 | 5.0 | 25.3 | 4.8 | 3.1 | 4.9 | 10.6 | ||||||||||
| 6 | 38.7 | 26.2 | 5.7 | 47.7 | 23.2 | 25.9 | 46.1 | 18.3 | 27.5 | 28.8 | ||||||||||
| 7 | 16.4 | 9.6 | 3.4 | 10.5 | 24.5 | 18.4 | 5.9 | 5.5 | 8.9 | 11.5 | ||||||||||
| 8 | 56.5 | 53.6 | 20.0 | 46.3 | 12.3 | 46.5 | 17.8 | 19.8 | 49.2 | 35.8 | ||||||||||
| 9 | 21.2 | 18.3 | 55.1 | 51.0 | 48.7 | 88.6 | 22.3 | 45.7 | 50.7 | 45.0 | 45.2 | 44.7 | ||||||||
| 10 | 24.9 | 35.2 | 16.8 | 24.3 | 28.6 | 33.0 | 27.3 | 41.8 | 22.0 | 28.2 | ||||||||||
| 11 | 8.7 | 22.9 | 26.3 | 37.0 | 40.0 | 43.3 | 26.4 | 55.0 | 22.5 | 17.2 | 19.5 | 29.0 | ||||||||
| 12 | 21.0 | 55.8 | 55.5 | 55.5 | 30.7 | 78.4 | 67.4 | 67.4 | 65.5 | 72.2 | 60.5 | 57.3 | ||||||||
| 13 | 12.9 | 16.4 | 20.3 | 20.0 | 22.1 | 38.7 | 8.8 | 21.3 | 24.1 | 16.4 | 15.5 | 19.7 | ||||||||
| 14 | 26.1 | 37.1 | 27.9 | 27.5 | 49.5 | 46.9 | 31.1 | 40.5 | 42.9 | 41.0 | 40.1 | 37.3 | ||||||||
| 15 | 9.7 | 6.5 | 12.4 | 15.8 | 7.3 | 26.9 | 28.7 | 35.6 | 31.2 | 7.4 | 6.9 | 17.1 | ||||||||
| 16 | 14.3 | 21.3 | 17.4 | 36.8 | 16.5 | 31.9 | 16.8 | 22.7 | 43.4 | 24.9 | 44.9 | 26.4 | ||||||||
| 17 | 4.1 | 4.6 | 37.1 | 41.3 | 4.2 | 15.9 | 17.0 | 4.9 | 29.7 | 29.8 | 43.9 | 21.1 | ||||||||
| 18 | 18.4 | 12.5 | 20.9 | 20.3 | 28.3 | 52.7 | 33.3 | 11.7 | 41.6 | 4.8 | 48.5 | 26.6 | ||||||||
| 19 | 40.4 | 35.6 | 10.8 | 45.0 | 42.3 | 52.6 | 18.0 | 24.9 | 30.0 | 8.6 | 52.4 | 32.8 | ||||||||
| 20 | 15.1 | 18.3 | 40.9 | 47.7 | 25.9 | 43.4 | 18.6 | 36.7 | 46.4 | 20.8 | 57.7 | 33.8 | ||||||||
| 21 | 5.8 | 35.1 | 14.0 | 47.3 | 52.4 | 56.0 | 46.5 | 26.3 | 38.4 | 22.5 | 58.4 | 36.6 | ||||||||
| 22 | 40.6 | 17.8 | 49.3 | 51.7 | 59.5 | 44.9 | 35.6 | 24.3 | 21.7 | 13.0 | 59.8 | 38.0 | ||||||||
| 23 | 4.6 | 40.8 | 37.4 | 38.4 | 64.1 | 9.2 | 65.3 | 60.8 | 64.0 | 61.0 | 66.4 | 46.6 | ||||||||
| 24 | 25.3 | 32.2 | 35.1 | 53.4 | 55.6 | 59.0 | 65.3 | 28.6 | 59.5 | 50.8 | 60.1 | 47.7 | ||||||||
| 25 | 7.8 | 9.1 | 19.7 | 53.6 | 47.9 | 14.7 | 26.9 | 11.7 | 17.8 | 17.6 | 49.1 | 25.1 | ||||||||
| 26 | 11.4 | 19.7 | 10.6 | 6.4 | 3.5 | 11.4 | 42.9 | 20.6 | 30.1 | 53.3 | 26.2 | 21.5 | ||||||||
| 27 | 12.9 | 14.7 | 42.2 | 41.7 | 41.9 | 47.0 | 53.3 | 32.3 | 40.1 | 52.5 | 50.4 | 39.0 | ||||||||
| 28 | 10.9 | 8.9 | 31.1 | 41.0 | 23.5 | 19.8 | 8.3 | 16.0 | 12.7 | 21.2 | 31.8 | 20.5 | ||||||||
| 29 | 28.3 | 7.2 | 20.0 | 30.2 | 32.3 | 44.6 | 49.3 | 23.7 | 62.6 | 35.4 | – | 43.5 | 34.3 | |||||||
| 30 | 15.2 | 8.2 | 9.7 | 30.4 | 37.5 | 21.2 | 34.7 | 8.5 | 29.7 | 27.9 | – | 43.7 | 24.2 | |||||||
| 31 | 13.4 | 11.6 | 11.8 | 20.0 | 43.1 | 24.6 | 24.7 | 15.9 | 15.3 | 11.1 | – | 43.6 | 21.4 | |||||||
| 32 | 46.0 | 7.7 | 9.7 | 35.2 | 50.4 | 45.8 | 39.6 | 37.8 | 53.6 | 25.4 | – | 20.1 | 33.8 | |||||||
| 33 | 45.6 | 15.1 | 12.3 | 16.8 | 24.0 | 44.7 | 44.9 | 42.4 | 58.7 | 64.7 | – | 41.2 | 37.3 | |||||||
| 34 | 18.2 | 18.7 | 43.0 | 31.7 | 46.9 | 46.4 | 48.7 | 63.3 | 59.5 | 40.7 | – | 43.3 | 41.9 | |||||||
| 35 | 38.3 | 22.7 | 14.9 | 41.1 | 56.8 | 24.6 | 27.5 | 33.3 | 55.6 | 25.1 | – | 51.0 | 35.6 | |||||||
| 36 | 20.5 | 25.6 | 13.4 | 34.9 | 39.3 | 46.9 | 54.7 | 50.4 | 73.0 | 58.1 | – | 39.9 | 41.5 | |||||||
| 37 | 15.0 | 9.9 | 20.6 | 11.4 | 33.7 | 24.8 | 32.6 | 28.7 | 58.1 | 32.3 | – | 35.1 | 27.5 | |||||||
| 38 | 46.1 | 21.4 | 33.1 | 26.5 | 27.6 | 36.3 | 22.9 | 46.9 | 31.3 | 40.4 | – | 28.3 | 32.8 | |||||||
| 39 | 37.0 | 18.3 | 11.2 | 23.1 | 41.0 | 31.2 | 40.5 | 43.6 | 21.5 | 10.8 | – | 38.4 | 28.8 | |||||||
| 40 | 34.9 | 35.5 | 52.9 | 60.5 | 68.2 | 50.3 | 65.5 | 34.3 | 43.5 | 41.3 | 62.3 | 49.9 | ||||||||
| 41 | 40.5 | 40.4 | 38.1 | 48.8 | 52.0 | 77.7 | 52.1 | 55.5 | 40.5 | 53.0 | 60.8 | 50.9 | ||||||||
| 42 | 38.8 | 19.8 | 30.6 | 46.5 | 42.7 | 51.0 | 43.3 | 48.0 | 12.5 | 36.0 | 43.3 | 37.5 | ||||||||
| 43 | 10.6 | 16.0 | 7.9 | 20.9 | 29.4 | 25.5 | 28.3 | 13.4 | 11.9 | 13.2 | 27.0 | 18.6 | ||||||||
| 44 | 28.7 | 13.3 | 28.3 | 28.8 | 34.6 | 25.8 | 28.4 | 33.9 | 11.0 | 32.3 | 31.9 | 27.0 | ||||||||
| 45 | 41.2 | 40.9 | 16.7 | 46.9 | 66.2 | 61.6 | 66.5 | 35.3 | 46.8 | 33.9 | 53.2 | 46.3 | ||||||||
| 46 | 53.2 | 27.8 | 24.3 | 37.2 | 46.6 | 29.3 | 54.8 | 39.1 | 30.8 | 40.9 | 41.0 | 38.6 | ||||||||
| 47 | 36.4 | 11.7 | 15.1 | 59.3 | 39.6 | 50.4 | 55.9 | 58.1 | 22.0 | 51.1 | 55.3 | 41.4 | ||||||||
| 48 | 18.6 | 43.7 | 22.4 | 52.9 | 60.2 | 46.2 | 60.2 | 5.9 | 45.4 | 45.7 | 68.4 | 42.7 | ||||||||
| 49 | 44.4 | 30.1 | 31.7 | 39.5 | 34.3 | 41.1 | 42.7 | 57.1 | 32.4 | 9.8 | 42.9 | 36.9 | ||||||||
| 50 | 22.0 | 10.0 | 16.0 | 9.0 | 21.0 | 28.0 | 33.0 | 19.0 | 10.0 | 13.0 | 17.0 | 18.0 | ||||||||
| 51 | 44.0 | 41.0 | 16.0 | 41.0 | 42.0 | 56.0 | 46.0 | 33.0 | 17.0 | 45.0 | 41.0 | 38.4 | ||||||||
| 52 | 35.0 | 13.0 | 38.0 | 21.0 | 28.0 | 35.0 | 42.0 | 42.0 | 19.0 | 31.0 | 36.0 | 30.9 | ||||||||
| Avg | 28.6 | 33.8 | 12.6 | 35.3 | 11.7 | 26.1 | 18.6 | 32.2 | 18.4 | 22.4 | 32.1 | 39.7 | 36.4 | 41.3 | 34.1 | 33.6 | 34.4 | 29.4 | 41.9 | 32.1 |
The highest inhibitory rate was indicated in bold for each patient.
CDDP cisplatin, OXA oxaliplatin, IRN irinotecan, DOX Doxorubicin, PTX paclitaxel, DTAX docetaxel, EP epirubicin, BEL belotecan, 5-FU 5-fluorouracil, GEM gemcitabine, TS-1 tegafur, gimeracil.