Table 3.
Baseline characteristics associated with hidradenitis suppurativa
| Characteristics | Adults N = 529 |
Adolescents N = 65 |
All patients N = 594 |
|---|---|---|---|
| Hurley stagea | |||
| I | 28 (5.3) | 12 (18.5) | 40 (6.7) |
| II | 346 (65.4) | 48 (73.8) | 394 (66.3) |
| III | 155 (29.3) | 5 (7.7) | 160 (26.9) |
| ISH4 severity scoreb [43] | |||
| ≤ 3 (mild) | 121 (22.9) | 22 (34.4) | 143 (24.1) |
| 4–10 (moderate) | 147 (27.8) | 20 (31.3) | 167 (28.1) |
| ≥ 11 (severe) | 261 (49.3) | 22 (34.4) | 283 (47.6) |
| Age at start of HS symptoms, years |
(N = 528) 24.5 ± 12.3 |
(N = 65) 12.1 ± 3.4 |
(N = 593) 23.2 ± 12.3 |
| Years from HS symptom onset to diagnosis | (N = 527) | (N = 65) | (N = 592) |
| Mean ± SD | 8.3 ± 10.5 | 2.5 ± 3.3 | 7.7 ± 1.2 |
| Median (1st, 3rd quartiles) | 4.1 (0.6, 12.2) | 1.3 (0.3, 3.0) | 3.7 (0.5, 10.8) |
| Family history of HS | 159 (30.1) | 23 (35.4) | 182 (30.6) |
| HS lesion count | (N = 529) | (N = 64) | (N = 593) |
| Abscesses | 3.7 ± 8.8 | 2.6 ± 7.7 | 3.6 ± 8.8 |
| Draining fistulas | 2.6 ± 6.1 | 0.9 ± 2.0 | 2.4 ± 5.8 |
| Non-draining fistulas | 6.7 ± 22.6 | 1.2 ± 2.6 | 6.1 ± 21.5 |
| Inflammatory nodules | 7.1 ± 11.0 | 5.4 ± 7.4 | 6.9 ± 10.7 |
| Non-inflammatory nodules | 6.9 ± 17.5 | 6.4 ± 24.9 | 6.9 ± 18.4 |
| Used pads for lesion drainagec | – | – | 230 (38.7) |
| Mammary | – | – | 34 (14.8) |
| Pelvicd | – | – | 87 (37.8) |
| Axilla | – | – | 97 (42.2) |
| Buttock | – | – | 32 (13.9) |
| Number of HS flarese per patient during previous 6 months |
(N = 529) 5.8 ± 9.5 |
(N = 64) 4.6 ± 5.6 |
(N = 593) 5.7 ± 9.1 |
Data are presented as mean ± standard deviation or N (%) unless otherwise indicated
HS hidradenitis suppurativa, ISH4 International Hidradenitis Suppurativa Severity Score System, SD standard deviation
aWorst Hurley stage of all regions. Hurley stage I: Localised formation of single or multiple abscesses without sinus tracts and scarring. Hurley stage II: Recurrent abscesses with sinus tract formation and scarring; single or multiple lesions. Hurley stage III: Diffuse involvement with interconnected tracts and abscesses
bData missing for one adolescent
cPatients could have reported using pads in multiple areas. Data were not analysed for adults versus adolescents because the number of adolescent patients was too small to provide meaningful information
dIncludes groin
e“Flare” was as reported by patient or investigator and was not pre-defined in the protocol