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. 2020 Jul 20;10:11951. doi: 10.1038/s41598-020-68150-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased TCN1 expression is associated with clinicopathological features, poor prognosis, and chemosensitivity of colon cancer. (a) TCN1 expression in colon cancer and adjacent normal mucosal tissues. (b) Expression status of distinct colon cancer clinical stage and adjacent normal mucosal tissues. (c) Expression of TCN1 in pulmonary metastatic tissues (PMT) and paired normal lung tissues (NLT). (d) Comparison of TCN1 expression in colon cancer and PMT. (e) Expression of TCN1 in left- and right-sided colon cancer. (f) Effect of TCN1 expression level on overall survival. (g) TCN1 expression level was decreased after platinum-containing chemotherapy (pre-chemical therapy vs post-chemical therapy). (h) TCN1 expression in colonoscopy biopsy tissues and specimens resected during surgery. *P < 0.05; **P < 0.01; ***P < 0.001.