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. 2020 Jul 20;10:11958. doi: 10.1038/s41598-020-67465-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of Coronin 1C in melanoma results in more distant metastases. (a) Schematic diagram of macro- and micro-metastasis identification in mouse models. Organs are removed and macro-metastases are identified with a stereo microscope via TdTomato signal. Organs are then dissociated to a single cell suspension and micro-metastases are identified by FACS sorting. (b) Example of a macro-metastasis identified in a PBT-1C mouse brain 13 weeks after induction. For comparison is a PBT brain with no visible metastases 19 weeks after induction. (c) Donut plots displaying the number of mice with identified macro-metastases in green compared to the number of mice screened with no visible metastases present in blue for each organ in both PBT and PBT-1C mice. The fractions in the middle represent the number of organs with macro-metastases over the total number of organs screened. (d) Donut plots displaying micro-metastases for the brain, liver, lung, pancreas, and spleen for both GEM models as described in (c).