Table 6.
Disease-associated genes in the consensus ROHs. Disease and disease candidate genes that are located in the consensus ROHs of the Dalmatians are depicted. Other genes that are located in the 13 consensus ROH are also given. The start and end of consensus ROHs in base pairs and the length of consensus ROH in base pairs comply to the detection of consensus ROH with the 10 SNP threshold
| Chromosome | Start (bp) | End (bp) | Length of consensus ROH in beadchip SNPs | Length of consensus ROH in bp | Genes that are located in the consensus ROH | Associated diseases of those genes |
|---|---|---|---|---|---|---|
| 1 | 23,754,226 | 24,443,343 | 55 | 689.117 | MEX3C, SMAD4, ELAC1, ME2, MRO, RF00001, MC2R, MC5R, ENSCAFG00000032822 | Glaucoma (SMAD4), Idiopathic epilepsy (ME2) |
| 3 | 67,712,997 | 67,855,181 | 13 | 142.184 | ENSCAFG00000033564, ENSCAFG00000036945, ENSCAFG00000037957 | – |
| 3 | 67,876,487 | 68,200,003 | 29 | 323.516 | ENSCAFG00000033306, ENSCAFG00000033607 | – |
| 3 | 69,068,007 | 69,485,604 | 38 | 417.597 | CLNK, ZNF518B, SLC2A9, WDR1, ENSCAFG00000039826, ENSCAFG00000033935 | Diabetes mellitus, entropion, hyperuricosuria (SLC2A9) |
| 4 | 38,457,632 | 38,587,643 | 15 | 130.011 | NSG2, ENSCAFG00000032093 | – |
| 13 | 3,182,619 | 3,330,775 | 13 | 148.156 | GRHL2, ENSCAFG00000030800 | Deafness (GRHL2) |
| 13 | 3,490,088 | 3,550,490 | 7 | 60.402 | ENSCAFG00000036103 | – |
| 17 | 35,638,035 | 35,834,516 | 17 | 196.481 | BCL2L11, ENSCAFG00000036821, ENSCAFG00000007091 | Deafness (BCL2L11) |
| 17 | 35,861,411 | 35,861,411 | 1 | 1 | ENSCAFG00000035515, ENSCAFG00000040340 | – |
| 17 | 39,631,741 | 39,800,897 | 18 | 169.156 | CAPG, ELMOD3, RETSAT, TCF7L1, ENSCAFG00000024531 | Deafness (ELMOD3) |
| 24 | 15,945,228 | 16,028,176 | 7 | 82.948 | SHLD1 | – |
| 24 | 34,585,142 | 34,731,796 | 12 | 146.654 | NCOA3, ENSCAFG00000035729, ENSCAFG00000010850 | – |
| 38 | 11,140,991 | 11,561,386 | 36 | 420.395 | USH2A | Deafness |