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. 2020 Jul 1;16:58. doi: 10.1186/s13223-020-00455-9

Table 5.

Comparison of seasons and times of day with most severe symptoms between 1990s and 2010s

Number of patients (%) P*
1990s (n = 1447) 2010s (n = 3388)
Season
 Spring 101 (7.0) 226 (6.7) 0.695
 Summer 38 (2.6) 119 (3.5) 0.111
 Fall 52 (3.6) 110 (3.2) 0.539
 Winter 288 (19.9) 659 (19.5) 0.717
 The change of seasons 456 (31.5) 1275 (37.6) < 0.001
 Throughout the year 454 (31.4) 918 (27.1) 0.003
 No answer 48 (3.3) 81 (2.4) N/A
Time
 Morning 637 (44.0) 1158 (34.2) < 0.001
 Daytime 101 (7.0) 255 (7.5) 0.505
 Evening 211 (14.6) 572 (16.9) 0.050
 Bedtime 168 (11.6) 412 (12.2) 0.590
 Throughout the day 292 (20.2) 900 (26.6) < 0.001
 No answer 38 (2.6) 91 (2.7) N/A

* Chi square test; N/A, not available