Table 6.
Association of CTLA4 polymorphisms with hypoadrenocorticism in springer spaniels. Markers are as Table 3, 5′ to 3′ order from top to bottom SNPs and then indels. MAF: minor allele frequency; NaN: not a number; N/A: not calculable; OR: odds ratio; 95% CI: 95% confidence intervals of the OR; Max (T) p value calculated by permutation analysis; FDR: false discovery rate
| Marker | Minor allele | MAF in cases | MAF in controls | Max (T) p value |
FDR | OR (95% CI) |
|---|---|---|---|---|---|---|
| SNP1 | A | 0.5 | 0.315 | 0.026 | 0.03462 | 2.16 (1.12–4.17) |
| SNP2 | A | 0.5 | 0.315 | 0.026 | 0.03462 | 2.16 (1.12–4.17) |
| SNP3 | A | 0 | 0.008 | 1 | 1 | 0 (0 - NaN) |
| SNP4 | A | 0.5 | 0.315 | 0.026 | 0.03462 | 2.16 (1.12–4.17) |
| SNP5 | A | 0.5 | 0.315 | 0.026 | 0.03462 | 2.16 (1.12–4.17) |
| SNP6 | A | 0.5 | 0.315 | 0.026 | 0.03462 | 2.16 (1.12–4.17) |
| SNP7 | G | 0.535 | 0.315 | 0.008 | 0.03462 | 2.5 (1.29–4.82) |
| SNP8 | A | 0.035 | 0 | 0.132 | 0.1072 | N/A |
| SNP9 | A | 0.482 | 0.298 | 0.027 | 0.03462 | 2.19 (1.13–4.23) |
| SNP10 | G | 0.5 | 0.315 | 0.026 | 0.03462 | 2.16 (1.12–4.17) |
| SNP11 | N/A | 0 | 0 | 1 | 1 | N/A |
| SNP12 | T | 0.5 | 0.315 | 0.026 | 0.03462 | 2.16 (1.12–4.17) |
| SNP13 | T | 0.125 | 0.140 | 1 | 1 | 0.87 (0.33–2.26) |
| SNP14 | C | 0.5 | 0.350 | 0.071 | 0.07347 | 1.85 (0.96–3.54) |
| SNP15 | C | 0.5 | 0.315 | 0.026 | 0.03462 | 2.16 (1.12–4.17) |
| SNP16 | G | 0.5 | 0.315 | 0.026 | 0.03462 | 2.16 (1.12–4.17) |
| SNP17 | N/A | 0 | 0 | 1 | 1 | N/A |
| SNP18 | G | 0 | 0.008 | 1 | 1 | 0 (0 - NaN) |
| SNP19 | A | 0.5 | 0.315 | 0.026 | 0.03462 | 2.16 (1.12–4.17) |
| SNP20 | N/A | 0 | 0 | 1 | 1 | N/A |
| indel1 | N/A | 0 | 0 | 1 | 1 | N/A |
| indel2 | – | 0.5 | 0.315 | 0.026 | 0.03462 | 2.16 (1.12–4.17) |
| indel3 | – | 0.375 | 0.543 | 0.031 | 0.0571 | 0.50 (0.26–0.96) |