TABLE 3.

Counts of pathways that emerged as significant in response to acute and chronic MPL dosing in muscle.

Pathway subgroup	Pathway group	Significant acute response pathways	Significant chronic response pathways
Cell growth and death	Cellular processes	5	3
Cell motility	Cellular processes	1	1
Transport and catabolism	Cellular processes	3	6
Signal transduction	Environmental information processing	17	15
Signaling molecules and interaction	Environmental information processing	1	0
Folding, sorting and degradation	Genetic information processing	1	4
Transcription	Genetic information processing	0	1
Translation	Genetic information processing	0	1
Amino acid metabolism	Metabolism	2	6
Carbohydrate metabolism	Metabolism	0	9
Energy metabolism	Metabolism	0	2
Lipid metabolism	Metabolism	4	2
Metabolism of cofactors and vitamins	Metabolism	0	1
Metabolism of other amino acids	Metabolism	1	1
Nucleotide metabolism	Metabolism	1	0
Xenobiotics biodegradation and metabolism	Metabolism	1	0
Endocrine system	Organismal systems	12	8
Environmental adaptation	Organismal systems	0	1
	Total	49	61

See Supplementary Tables for complete list of significant pathways and all calculated metrics.