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. 2020 Jul 20;10:11954. doi: 10.1038/s41598-020-68769-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased Ccl2 levels in the metabolic tissues from the Ccl2 cisgenic mice (CgCcl2). The results are shown for (A) the Ccl2 concentrations in the liver, white adipose tissue (eWAT), pancreas, muscle and brown adipose tissue (BAT) of the wild-type (WT) and CgCcl2 mice and (B) the relative weight of the selected tissues. The results are shown as the mean ± SEM (n = 8 for each group). *P < 0.05; **P < 0.001, with respect to the WT control littermates.