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. 2020 Jul 20;10:11992. doi: 10.1038/s41598-020-68950-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distances of switch regions to selected switch-I (A–C) and switch-II (D–F) residues. The corresponding locations of the monitored Cα atoms (spheres) and their distances in the AMG 510 crystal structure (PDB ID: 6oim) are illustrated with cyan and yellow dashed lines in A–F. The black horizontal line in the box represents the median. Box displays the quartiles of the dataset (25%–75%) and whiskers the rest of the data with maximum 1.5 IQR. Outliers are indicated with black diamonds. (G) Monitored distances represented in the KRAS(G12C)–AMG 510 structure.