Fig. 2.

Effects of IL-22 knockout on cardiac injury in DOX-treated mice. (A). Changes in BW at different time points in different groups; N = 10 in each group. (B). The HW of each mouse was measured at the end of the fifth day; N = 10 in each group. (C). HW/BW ratios in the three groups; N = 10 in each group. (D). Vacuolated cardiomyocytes were detected in different groups by H&E staining and quantified; N = 5 in each group. (E). Serum and LV tissue LDH and CK-MB levels were analyzed; N = 5–10 in each group. *P < 0.05 vs. the control group. ^#P < 0.05 vs. the DOX group.