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. 2020 Jul 3;23(7):101338. doi: 10.1016/j.isci.2020.101338

Figure 2.

Figure 2

HIF1α Interacts with the Core Clock Machinery

(A–E) (A–C and E) Proteins detected by immunoblotting (IB) in whole-cell lysates (WCL) or following immunoprecipitation (IP) of the FLAG tag from lysates of HEK293T cells expressing the indicated plasmids and treated with vehicle control (−), 100 μM CoCl2, or 200 μM DMOG as indicated. (D) Endogenous BMAL1, HIF1α, and β-ACTIN detected in WCL or following IP of HIF1α from lysates of ear fibroblasts of the indicated genotypes treated with vehicle control (−) or 100 μM CoCl2.