TABLE 1.

Characteristics of 11 genetic variants in AS and AD GWAS datasets.

SNP	Chr	Nearby genes	EAa	NEA	EAFb	AS GWAS			AD GWAS
						Betac	SEc	P-valuec	Betad	SEd	P-valued
rs880315	1	CASZ1	C	T	0.4	0.0527	0.0084	3.619E-10	–0.0083	0.0171	0.6301
rs12037987	1	WNT2B	C	T	0.16	0.071	0.0128	2.734E-08	–0.0058	0.0333	0.8606
rs16896398	6	SLC22A7-ZNF318	T	A	0.34	0.0477	0.0084	1.301E-08	–0.0072	0.017	0.6719
rs7859727	9	Chr9p21	T	C	0.53	0.0494	0.0079	4.221E-10	0.024	0.0156	0.1244
rs2295786	10	SH3PXD2A	A	T	0.6	0.0526	0.0082	1.797E-10	–0.0263	0.0162	0.1043
rs35436	12	TBX3	C	T	0.62	0.0462	0.0083	2.865E-08	0.0112	0.0165	0.4949
rs9526212	13	LRCH1	G	A	0.76	0.0587	0.0094	5.034E-10	–0.0187	0.0181	0.3015
rs8103309	19	SMARCA4-LDLR	T	C	0.65	0.0501	0.0091	3.397E-08	0.0249	0.0172	0.1487
rs1052053	1	PMF1- SEMA4A	G	A	0.4	0.0624	0.0082	2.699E-14	–0.0209	0.016	0.1898
rs4959130	6	FOXF2	A	G	0.14	0.0779	0.0129	1.424E-09	–0.033	0.0236	0.1625
rs12445022	16	ZCCHC14	A	G	0.31	0.0574	0.0089	1.048E-10	0.0303	0.0167	0.07066

SNP, single-nucleotide polymorphism; Chr, chromosome; EA, effect allele; NEA, non-effect allele; EAF, effect allele frequency; AS, any stroke; AD, Alzheimer’s disease; GWAS, genome-wide association studies; SE, standard error. ^aEffect allele associated with stroke. ^bThe frequency of effect allele associated with stroke. ^cThe summary statistics for SNP, including Beta, standard error, and P-value, were obtained from any stroke GWAS dataset. Beta > 0 indicates this effect allele increases the stroke risk. Otherwise, it reduces the stroke risk (Beta < 0). ^dThe summary statistics for SNP, including Beta, standard error, and P-value, were obtained from AD GWAS dataset. The Beta was obtained based on the effect allele associated stroke. Beta > 0 indicates this effect allele increases the AD risk. Otherwise, it reduces the AD risk (Beta < 0).