TABLE 2.

Characteristics of 11 genetic variants in AIS and AD GWAS datasets.

SNP	Chr	Nearby genes	EAa	NEA	EAFb	AIS GWAS			AD GWAS
						Betac	SEc	P-valuec	Betad	SEd	P-valued
rs34311906	4	ANK2	C	T	0.41	0.0677	0.0120	1.07E-08	NA	NA	NA
rs6825454	4	FGA	C	T	0.31	0.0583	0.0096	7.43E-10	0.0047e	0.0184e	0.7961e
rs11957829	5	LOC100505841	A	G	0.82	0.0677	0.0119	7.51E-09	0.0093	0.022	0.6732
rs42039	7	CDK6	C	T	0.77	0.0677	0.0120	6.55E-09	0.039	0.0187	0.03639
rs7304841	12	PDE3A	A	C	0.59	0.0488	0.0097	4.93E-08	−0.0142	0.0176	0.4183
rs4932370	15	FURIN–FES	A	G	0.33	0.0488	0.0097	2.88E-08	−0.0071	0.0171	0.6793
rs11867415	17	PRPF8	G	A	0.18	0.0862	0.0163	4.81E-08	−0.0392	0.0347	0.258
rs2229383	19	ILF3–SLC44A2	T	G	0.65	0.0488	0.0097	4.72E-08	0.0158	0.0169	0.3508
rs635634	9	ABO	T	C	0.19	0.0770	0.0142	9.18E-09	−0.0055	0.0195	0.7793
rs2005108	11	MMP12	T	C	0.12	0.0770	0.0142	3.33E-08	−0.0003	0.0231	0.9888
rs3184504	12	SH2B3	T	C	0.45	0.0770	0.0094	2.17E-14	−0.0252	0.0159	0.1134

^aEffect allele associated with AIS. ^bThe frequency of effect allele associated with AIS. ^cThe summary statistics for SNP, including Beta, standard error, and P-value, were obtained from the published article (Malik et al., 2018). ^dThe summary statistics for SNP, including Beta, standard error, and P-value, were obtained from AD GWAS dataset. ^eThe summary information of the proxy SNP rs56010410 for rs6825454 (r² = 0.97), and the effect allele of rs56010410 is C.