Table 2.
Comparison of the baseline clinical characteristics and small and large nerve fiber parameters of 101 patients with diabetes and RCNFL and the 489 without
| Characteristic | Diabetes with RCNFL | Diabetes with stable CNFL | P value |
|---|---|---|---|
| (n = 101) | (n = 489) | ||
| Female sex | 39 (39) | 216 (44) | 0.30 |
| Age (year) | 47.33 ± 18.01 | 46.90 ± 18.76 | 0.83 |
| BMI (kg/m2) | 28.56 ± 5.98 | 27.25 ± 5.90 | 0.052 |
| Triglycerides | 1.47 ± 1.08 | 1.29 ± 0.91 | 0.14 |
| T1D/T2D, n | 64/37 | 335/154 | 0.30 |
| Diabetes duration (year) | 19.76 ± 14.85 | 18.70 ± 14.04 | 0.50 |
| HbA1c (%) | 8.18 ± 1.68 | 7.96 ± 1.51 | 0.20 |
| Baseline DSP | 47 (47) | 144 (30) | 0.001 |
| DSP signs | 3.81 ± 3.67 | 2.64 ± 3.09 | 0.004 |
| DSP symptoms | 2.28 ± 3.59 | 1.75 ± 3.35 | 0.13 |
| Small nerve fiber measures | |||
| Baseline CNFL (mm/mm2) | 14.37 ± 4.22 | 13.52 ± 4.32 | 0.073 |
| Cooling detection (°C) | 25.90 (20.00, 28.10) | 27.20 (23.40, 29.20) | <0.001 |
| Large nerve fiber measure | |||
| Vibration perception (V) | 15.72 ± 11.60 | 15.18 ± 16.68 | 0.70 |
| Sural AMP (μV) | 8.07 ± 8.28 | 9.68 ± 8.49 | 0.085 |
| Sural CV (m/s) | 39.62 ± 7.73 | 40.76 ± 7.89 | 0.10 |
| Peroneal AMP (mV) | 3.66 ± 2.33 | 4.13 ± 2.57 | 0.092 |
| Peroneal CV (m/s) | 40.86 ± 7.02 | 42.83 ± 7.20 | 0.013 |
| Peroneal F-wave (ms) | 56.00 (51.40, 71.30) | 54.20 (49.20, 63.95) | 0.030 |
Data are presented as mean ± SD, median (interquartile range), or n (%). P value for comparison between diabetes control patients and the subcohort of patients with diabetes and RCNFL. CV, conduction velocity.