Table 3.
The estimated change in clinical, neurological, and electrophysiological variables associated with a 1% per year loss of CNFL in the 590 participants with diabetes
| Characteristic | Parameter estimate | Lower CL | Upper CL | P value |
|---|---|---|---|---|
| HbA1c | −1.01 | −2.94 | 0.92 | 0.30 |
| BMI (kg/m2) | 0.13 | −1.12 | 1.38 | 0.83 |
| DSP signs | 1.51 | 0.34 | 2.69 | 0.012 |
| DSP symptoms | 1.66 | 0.24 | 3.07 | 0.022 |
| Small nerve fiber measures | ||||
| CNFD (fibers/mm2) | −2.00 | −2.17 | −1.82 | <0.0001 |
| CNBD (branches/mm2) | −0.96 | −1.06 | −0.87 | <0.0001 |
| Cooling detection (°C) | 0.30 | −0.43 | 0.84 | 0.53 |
| Large nerve fiber measures | ||||
| Vibration perception (V) | 0.027 | −0.13 | 0.18 | 0.73 |
| Sural CV (m/s) | 0.41 | −0.001 | 0.82 | 0.051 |
| Sural AMP (mV) | 0.39 | 0.030 | 0.81 | 0.069 |
| Peroneal AMP (mV) | −1.87 | −3.60 | −0.15 | 0.034 |
| Peroneal CV (m/s) | −0.93 | −1.66 | −0.20 | 0.013 |
| Peroneal F-wave (ms) | 0.34 | 0.04 | 0.63 | 0.027 |
The regression parameter estimate shows the percent change in CNFL associated with a one-unit loss in the given variable. CL, confidence limit; AMP, amplitude.