Table 1.
Characteristics of T1D participants by HLA-DQB1*06:02 status
| DQB1*06:02+ (n = 50) | DQB1*06:02− (n = 2,759) | P value | |
|---|---|---|---|
| Age at diagnosis, years (mean ± SD) | 10.8 ± 6.0 | 12.5 ± 8.7 | 0.069 |
| Sex (% female) | 52 (n = 26) | 46 (n = 1,266) | 0.395 |
| Race/ethnicity (%) | 0.540 | ||
| White | 86 (n = 43) | 80 (n = 2,213) | |
| Hispanic | 6 (n = 3) | 5 (n = 142) | |
| Other | 6 (n = 3) | 8 (n = 218) | |
| Unknown | 2 (n = 1) | 7 (n = 186) | |
| Islet autoantibody status (%) | |||
| GADA | 55 (27/49) | 52 (1,399/2,676) | 0.773 |
| IA-2A | 39 (19/49) | 60 (1,587/2,663) | 0.005 |
| IAA* | 35 (13/37) | 34 (479/1,398) | 1.00 |
| ZnT8A | 51 (18/35) | 62 (553/898) | 0.289 |
| Number of islet autoantibodies (%)** | 0.009 | ||
| 0 Ab | 30 (14/47) | 14 (247/1,827) | 0.004 |
| 1 Ab | 19 (9/47) | 26 (474/1,827) | 0.398 |
| 2 Ab | 21 (10/47) | 33 (607/1,827) | 0.115 |
| ≥3 Ab | 30 (14/47) | 27 (499/1,827) | 0.741 |
Ab, autoantibodies.
*
IAA positive values were excluded from analysis if measured >21 days after T1D diagnosis.
**
Includes samples for which at least three islet autoantibodies were measured; overall P value is reported, followed by those for each category.