Table 1.

Metabolic parameters of insulin-clamped WT and mdKO mice

	Chow diet		HF diet
	WT	mdKO	WT	mdKO
N	11	9	11	15
Body weight (g)	27.1 ± 0.7	26.6 ± 0.6	45.0 ± 0.9	45.4 ± 1.0
Arterial blood glucose (mg/dL)
Fasting	121 ± 5	137 ± 3*	154 ± 5	147 ± 7
Clamp	143 ± 3	139 ± 4	154 ± 3	150 ± 2
Arterial plasma insulin (ng/mL)
Fasting	0.3 ± 0.1	0.3 ± 0.1	3.7 ± 0.5	6.0 ± 1.5
Clamp	1.8 ± 0.2	1.2 ± 0.1*	9.5 ± 1.8	15.1 ± 3.5
Arterial NEFA (mmol/L)
Fasting	0.73 ± 0.06	0.74 ± 0.06	0.65 ± 0.04	0.73 ± 0.05
Clamp	0.17 ± 0.03	0.16 ± 0.03	0.38 ± 0.03	0.37 ± 0.02
Liver triglycerides (mg/g tissue)	7.9 ± 0.3	6.0 ± 0.7*	27.6 ± 3.6	25.7 ± 1.9
Liver glycogen (mg/g tissue)	19.6 ± 2.1	14.4 ± 3.3	22.6 ± 1.6	20.0 ± 0.6

Data are mean ± SEM unless otherwise indicated.

NEFA, nonesterified fatty acid.

^*P < 0.05 vs. WT (same diet).