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. 2020 May 22;69(8):1650–1661. doi: 10.2337/db19-1129

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© 2020 by the American Diabetes Association

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NAC treatment prevented hepatic steatosis and inflammation and preserved antioxidant capacity in HFD offspring. A: NAC normalized liver weight. B and C: The rise in hepatic triglycerides (B) and the increase in hepatic lipid vacuolization (C) (original magnification ×200) observed by H-E staining in HFD+vehicle offspring. NAC also normalized mRNA expression of proinflammatory and lipid-associated genes (D) and genes previously identified as differentially expressed and differentially methylated in HFD+vehicle offspring (E). NAC exposure increased hepatic GSH (F), GR (G), and GPx (H) activity and serum GR (I) and GPx (J) activity. n = 5–6/group except n = 3/group in C. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; #P < 0.05 by ANOVA. veh, vehicle.