Table 2:

CN-silent versus CN-high HNSCC from PanCancer Atlas TCGA HNSCC cohort

		PanCancer Atlas TCGA HNSCC
		CN-silent			CN-high			Chi-sq
								CN-silent vs CN-high
		Mean	Count	%	Mean	Count	%	Sig.
Count			84			439
Sex	Male		49	58.3%		334	76.0%
	Female		35	41.7%		105	24.0%	< 0.0001*
Age		62			60
CDKN2A	Wild-type		64	76.2%		353	80.4%
	Mutation		20	23.8%		86	19.6%	0.3808
FAT1	Wild-type		59	70.2%		357	81.3%
	Mutation		25	29.8%		82	18.7%	0.021*
TP53	Wild-type		37	44.0%		129	29.4%
	Mutation		47	56.0%		310	70.6%	0.0085*
CASP8	Wild-type		68	81.0%		413	94.1%
	Mutation		16	19.0%		26	5.9%	0.0001*
AJUBA	Wild-type		84	100.0%		416	94.8%
	Mutation		0	0.0%		23	5.2%	0.0328*
PIK3CA	Wild-type		66	78.6%		368	83.8%
	Mutation		18	21.4%		71	16.2%	0.2459
NOTCH1	Wild-type		68	81.0%		371	84.5%
	Mutation		16	19.0%		68	15.5%	0.4239
KMT2D	Wild-type		77	91.7%		370	84.3%
	Mutation		7	8.3%		69	15.7%	0.0780
NSD1	Wild-type		84	100.0%		380	86.6%
	Mutation		0	0.0%		59	13.4%	0.0004*
HRAS	Wild-type		66	78.6%		426	97.0%
	Mutation		18	21.4%		13	3.0%	< 0.0001*
FBXW7	Wild-type		77	91.7%		415	94.5%
	Mutation		7	8.3%		24	5.5%	0.3207
PTEN	Wild-type		81	96.4%		429	97.7%
	Mutation		3	3.6%		10	2.3%	0.4856
ARID2	Wild-type		81	96.4%		423	96.4%
	Mutation		3	3.6%		16	3.6%	0.9820
HLA-B	Wild-type		81	96.4%		424	96.6%
	Mutation		3	3.6%		15	3.4%	0.9266