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. 2020 Jul 14;11:1470. doi: 10.3389/fimmu.2020.01470

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Copyright © 2020 Estévez, Anibarro, Garet, Pallares, Barcia, Calviño, Maueia, Mussá, Fdez-Riverola, Glez-Peña, Reboiro-Jato, López-Fernández, Fonseca, Reljic and González-Fernández.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of the differentially expressed (DE) genes in the pairwise contrasts comparing the TB study groups. (A) Total number of DE genes (adjusted p < 0.01 and absolute Log2 Fold Change (L2FC) >1) and number of up- or down-regulated genes. (B) Venn diagram with the overlapping genes between the different signatures. The volcano plots highlight the genes with significant differences between (C) active TB patients vs. uninfected (NoTBI) contacts and (D) active TB patients vs. contacts with latent infection (LTBI). The Top-30 most modulated (genes with the greatest absolute fold change) genes were labeled.