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. 2020 Jul 14;11:1653. doi: 10.3389/fmicb.2020.01653

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Copyright © 2020 Lau, Joshi, Mahoney, Mason, van Marle, Osiowy and Coffin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differences in secreted HBV infection markers in HepG2 cell supernatant after transfection with wild-type vs. PC or BCP mutant HBV genomes. HepG2 cells were co-transfected with pcDNA-GFP +/- linearized wild-type (WT), G1896A or A1762T/G1764A (DMUT) HBV. Cell supernatant was analyzed post-transfection for (A) HBeAg; (B) HBsAg; (C) HBV DNA; and (D) HBV RNA. HBeAg was decreased in mutant compared to wild-type and differences in HBV DNA (p = 0.0363) and HBV RNA (p = 0.0220) were noted between G1896A vs. A1762T/G1764A mutants. Compiled results of three independent transfections.