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. 2020 Jul 11;19:101163. doi: 10.1016/j.pmedr.2020.101163

Table 2.

Description of minority populations, interventions, and study outcomes.

Study ID Study Design Minority Sample Size Setting Population Intervention Outcomes and Findings
Chao et al., 2015 [29] Randomized 8436 Southern California (USA) Black (n = 1231), Hispanic (n = 6184), and Asian (n = 1048) girls and women, 9 to 26 years old (16.7 mean), in a large managed care organization with one dose of HPV vaccine Reminder: Vaccine reminder letter, in English and Spanish, mailed every three months Series completion within 12 months
  • Black participants: 51.9% (524/1010) in intervention (I) vs. 37.6% (83/221) in control (C) (p < 0.01)

  • Hispanic participants: 56.9% (2830/4971) I vs. 45.9% (557/1213) C (p < 0.01)

  • Asian participants: 63.2% (520/823) I vs. 53.3% (120/225) C (p < 0.01)

DiClemente et al., 2015 [30] Randomized 216 Atlanta, Georgia (USA) African American adolescent girls, 13 to 18 years old (16.5 mean), with no previous HPV vaccine, seeking family planning and STI services in health clinics Education + Reminder: Multi-component, computer-delivered intervention including a culturally-appropriate video and promotional keychain as appointment reminder Series initiation within seven months
  • 11.1% (12/108) I vs. 11.1% (12/108) C

Series completion within seven months;
  • 5.6% (6/108) I vs. 1.9% (2/108) C (p = 0.12)

Vaccine-related beliefs: perceived susceptibility to HPV and cervical cancer
  • 22.2% (24/108) I vs. 15.7% (17/108) C perceived themselves to be at risk of getting HPV (p = 0.04)

  • 23.1% (25/108) I vs. 15.7% (17/108) C perceived themselves to be at risk of developing cervical cancer (p = 0.01)

Vaccine acceptability
  • 63% of participants would be “likely to get the HPV vaccine if a healthcare provider offered it to them in the next 12 months,” vaccine acceptability not reported by intervention/control conditions

Knowledge about HPV and cervical cancer
  • Participants scored an average of 4.61/11 on knowledge of HPV and cervical cancer, HPV knowledge not reported by intervention/control conditions

Joseph et al., 2016 [31] Randomized 200 Not Reported (USA) Haitian American (n = 100) and African American (n = 100) mothers with daughters aged 11 to 15 years old, with no previous HPV vaccine, English and Haitian-Creole speaking, U.S. born or immigrant status, attending primary care visits in a large, urban hospital Brief Negotiated Interviewing (BNI) with mothers to address beliefs, attitudes, and readiness for behavior change, and to identify next steps for vaccination Series initiation within one month
  • 56% (55/96) I vs. 51% (52/97) C (p = 0.47)

Series completion within 12 months
  • 10% (10/100) I vs. 6% (7/97) C (p = 0.39)

HPV knowledge
  • Mean knowledge score of 10 (SD = 2.0) in postintervention vs. mean score of 6 (SD = 4.0) preintervention (p < 0.0001)

Kim et al., 2018 [32] Randomized 87 6 states in the Northeast (USA) Korean American female college students, aged 18 to 26 years old (mean = 21.7), having received no previous doses of HPV vaccine, recruited through Korean community sources Education: A culturally-appropriate online educational story-telling intervention Series initiation OR scheduled appointment to receive vaccine within two months
  • 15.6% (7/45) I vs. 7.1% (3/42) C (p = 0.317)

Intent to receive the vaccine at two-month follow-up among those not vaccinated (n = 77)
  • No statistically significant difference between I and C, 49.4% said they intended to receive vaccine, 28.6% said “I don’t know”

Knowledge of HPV and cervical cancer
  • Statistically significant difference between I and C for only 2/16 HPV knowledge items, 0/9 HPV vaccine knowledge items, and 1/8 cervical cancer knowledge items

Vaccine-related attitudes: perceived susceptibility
  • No statistically significant difference in perceived susceptibility to HPV

Vaccine acceptability
  • No statistically significant difference in vaccine acceptability

Lee et al., 2018 [33] Randomized 19 Massachusetts (USA) Khmer American mother-daughter dyads with daughters, aged 14 to 17 years old (15.3 mean) with no previous HPV vaccine, English and Khmer speaking and/or reading, U.S. born or immigrant status, recruited through Khmer community sources Education: Theory-guided, culturally grounded storytelling narrative video intervention, in English and Khmer delivered to mothers and daughters Series initiation within one month
  • 22.2% (2/9) I vs. 22.2% C (2/9) Intent to receive vaccine within one month

  • 44.4% (4/9) I vs. 11.1% (1/9) C*

Parra-Medina et al., 2015 [34] Non-randomized 372 Texas (USA) Hispanic mothers-daughter dyads, with girls aged 11 to 17 years old with no previous HPV vaccine history, living along the Texas-Mexico border, recruited by community health workers Education + Other Services: Mother/daughter educational intervention and referral, navigation, and follow-up phone call services delivered by community health workers (CHWs) and undergraduate peer educators, in English and Spanish Series initiation within six months
  • 84% (312/372) I vs. 84% (312/372) C

Series completion within six months
  • 72.2% (185/257) I vs. 42.5% (46/185) C (p < 0.001; adjusted odds ratio [OR] = 2.24, 95% confidence interval [CI]: 1.25–4.02)

Reiter et al., 2018 [35] Randomized 150 31 states and the District of Columbia (USA) Males, aged 18 to 25 years old, self-identifying as gay (n = 124) or bisexual (n = 26), having never received any dose of HPV vaccine, recruited through Facebook Education + Reminder: Population-targeted, individually-tailored content about HPV and HPV vaccine delivered online, plus monthly email or text HPV vaccination reminders Series initiation within seven months
  • 44.7% (34/76) I vs. 25.7% (19/74) C (p = 0.02, OR = 2.34, 95% CI: 1.18–4.67)

Series completion within seven months
  • 10.5% (8/76) I vs. 2.7% (2/74) C (p = 0.07, OR = 4.24, 95% CI: 0.87–20.66)

Richman et al., 2016 [36] Randomized 145 Southern USA Black (n = 69) or “other” race (n = 53) and homosexual/bisexual (n = 23) English-speaking male and female students, 18 to 26 years old, attending a large university who were voluntarily initiating the first HPV vaccine dose from the campus health center Education + Reminder: Series of 7 electronic messages with health education messages about HPV and HPV vaccine and appointment reminder messages Series completion within seven months
  • Black participants: 74.2% (23/31) I vs. 36.8% (14/38) C*

  • “Other” race participants: 37.9% (11/29) I vs. 50% (12/24) C*

  • Homosexual/bisexual participants: 38.9% (7/18) I vs. 20% (1/5) C*

  • HPV knowledge

  • Increased for 33.8% (44/130) I participants vs. 32.8% (44/134) C participants

Winer et al., 2016 [37] Randomized 97 Hopi Reservation (North America) Hopi (American Indian) mothers-daughter dyads, with girls aged 9 to 12 years old, any number of previous HPV vaccine doses (unvaccinated and incompletely vaccinated), recruited through Hopi community sources Education: Mother-daughter dinner events featuring educational presentations on HPV Series initiation within 11 months
  • Among those with no previous HPV vaccine dose: 50% (11/22) I vs. 27.3% (6/22) C (relative risk [RR] = 1.8, 95% CI:0.8–4.4)*

Series completion within 11 months
  • Among those previously unvaccinated: I vs. C (RR = 3.0, 95%CI: 0.8–10.8)**

  • Among all girls (any dose of previous HPV vaccine): 32% (8/25) I vs. 27.6% (8/29) C (RR = 1.2, 95% CI: 0.6–2.3)*

*p-value not reported.

**numbers and percentages not reported by authors due to a cell size < 5.