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. 2020 Jul 15;7:844–851. doi: 10.1016/j.toxrep.2020.07.004

Table 3.

Relative organ weights (as a percentage of total final body weight) of male and female rats administered a daily dose of PhyG by oral gavage for 90 days.

Treatment group
Parameter Control T1 T2 T3
Mean SD (n) Mean SD (n) Mean SD (n) Mean SD (n)
Males
 Final body weight (g) 615.1 67.91 10 579.8 62.48 10 576.0 48.71 10 621.8 79.79 10
 Adrenal glands (% bw) 0.0109 0.0015 10 0.0122 0.0018 9 0.0109 0.0018 10 0.0110 0.0018 10
 Brain (% bw) 0.3675 0.0339 10 0.3954 0.0413 9 0.3863 0.0317 10 0.3609 0.0381 10
 Epididymis (% bw) 0.2426 0.0340 10 0.2726 0.0431 9 0.2594 0.0254 10 0.2412 0.0260 10
 Heart (% bw) 0.3021 0.0178 10 0.3023 0.0168 9 0.3233 0.0335 10 0.3115 0.0213 10
 Kidneys (% bw) 0.7044 0.0569 10 0.7356 0.0524 9 0.7095 0.0609 10 0.7217 0.0562 10
 Liver (% bw) 2.9031 0.2362 10 3.2559 1.1733 9 2.8472 0.1669 10 3.2458 0.5826 10
 Lung with bronchi (% bw) 0.3023 0.0227 10 0.3305 0.0453 9 0.3140 0.0260 10 0.2996 0.0358 10
 Pituitary gland (% bw) 0.0023 0.0005 10 0.0026 0.0003 9 0.0027 0.0005 10 0.0025 0.0003 10
 Prostate and seminal vesicles with coagulating gland (% bw) 0.4360 0.0733 10 0.4733 0.0612 9 0.4572 0.0732 10 0.4090 0.0665 10
 Salivary glands (% bw) 0.1262 0.0207 10 0.1501** 0.0134 9 0.1296 0.0152 10 0.1268 0.0135 10
 Spleen (% bw) 0.1420 0.0150 10 0.1918 0.1022 9 0.1503 0.0204 10 0.1587 0.0214 10
 Testes (% bw) 0.5871 0.0929 10 0.6470 0.0845 9 0.6420 0.0750 10 0.6084 0.0795 10
 Thymus (% bw) 0.0752 0.0196 10 0.0737 0.0092 9 0.0775 0.0138 10 0.0700 0.0161 10
 Thyroid and parathyroid glands (% bw) 0.0054 0.0010 10 0.0046 0.0006 9 0.0050 0.0006 10 0.0047 0.0007 10



Females
 Final body weight (g) 288.0 20.34 10 301.9 64.82 10 294.5 29.62 10 276.5 18.79 10
 Adrenal glands (% bw) 0.0298 0.0050 10 0.0284 0.0054 10 0.0264 0.0027 10 0.0293 0.0050 10
 Brain (% bw) 0.7157 0.0520 10 0.6988 0.0927 10 0.7006 0.0681 10 0.7347 0.0558 10
 Heart (% bw) 0.3732 0.0294 10 0.3574 0.0461 10 0.3511 0.0171 10 0.3633 0.0198 10
 Kidneys (% bw) 0.7746 0.1082 10 0.7427 0.0580 10 0.7256 0.0613 10 0.7649 0.0559 10
 Liver (% bw) 2.9011 0.2497 10 2.8462 0.2713 10 2.7797 0.3057 10 2.9099 0.2361 10
 Lung with bronchi (% bw) 0.4752 0.0405 10 0.4832 0.0845 10 0.4679 0.0345 10 0.4891 0.0476 10
 Ovaries (% bw) 0.0285 0.0057 10 0.0319 0.0070 10 0.0321 0.0080 10 0.0316 0.0048 10
 Pituitary gland (% bw) 0.0068 0.0020 10 0.0062 0.0018 10 0.0068 0.0011 10 0.0068 0.0018 10
 Salivary glands (% bw) 0.1589 0.0158 10 0.1588 0.0274 10 0.1576 0.0185 10 0.1586 0.0192 10
 Spleen (% bw) 0.1860 0.0355 10 0.1785 0.0294 10 0.1833 0.0330 10 0.1785 0.0228 10
 Thymus (% bw) 0.1087 0.0295 10 0.1025 0.0140 10 0.0968 0.0170 10 0.1059 0.0160 10
 Thyroid and parathyroid glands (% bw) 0.0071 0.0010 10 0.0060 0.0009 10 0.0062 0.0015 10 0.0074 0.0018 10
 Uterus/cervix (% bw) 0.2926 0.1609 10 0.2422 0.0826 10 0.2803 0.0965 10 0.2637 0.0856 10

SD = Standard deviation.

T1 = experimental phytase at 250 mg TOS/kg bw/day (equivalent to 112,500 FTU/kg bw/day).

T2 = experimental phytase at 500 mg TOS/kg bw/day (equivalent to 225,000 FTU/kg bw/day).

T3 = experimental phytase at 1000 mg TOS/kg bw/day (equivalent to 450,000 FTU/kg bw/day).

**

significantly different from control, at P < 0.01.