Table 4.
Statistical analysis of tactile thresholds obtained using von Frey filaments.
| Compound 1 | Compound 2 | Compound 3 | Capsaicin | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Time (h) /EC50 | x1 | x10 | x100 | x1000 | x1 | x10 | x100 | x1000 | x1 | x10 | x100 | x1000 | x1 | x10 | x100 |
| 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| 1 | – | * | * | ** | – | – | – | *** | – | – | – | – | – | – | – |
| 2 | – | **** | ** | *** | – | – | * | ** | – | – | – | – | – | – | – |
| 3 | – | **** | ** | **** | – | – | – | *** | – | – | – | – | – | – | * |
| 4 | – | *** | * | *** | – | – | * | * | – | – | – | – | – | – | * |
| 5 | – | **** | ** | *** | – | – | – | – | – | – | – | – | – | – | * |
| 6 | – | ** | ** | *** | – | – | – | – | – | – | – | – | – | – | – |
| 7 | – | ** | *** | *** | – | – | ** | ** | – | – | – | * | – | – | – |
| 8 | – | * | ** | *** | – | – | – | ** | – | – | * | * | – | – | – |
| 9 | – | – | ** | ** | – | – | – | – | – | – | * | * | – | – | ** |
| 24 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Analgesic effects of the compounds relative to vehicle. The different time points are shown in column 1, concentrations (as multipliers of EC50) are shown for each compound (compound 1, columns 2-5; compound 2, columns 6-9; compound 3; columns 10-13 and capsaicin, columns 14-16). Statistical differences were analyzed using 2-way ANOVA and Bonferroni post-hoc test; -, is non-significant; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.