Table 1.

Physicochemical and Pharmacokinetic Characteristics of Antimicrobials Commonly Used to Treat Sepsis

Antimicrobial	Hydrophilic	Lipophilic	Highly Protein Bound (>70%)	Hepatic Metabolism	Renal Elimination
Amikacin	√				√
Azithromycin		√		√
Aztreonam	√				√
Cefazolin			√		√
Cefepime	√				√
Ceftazidime	√				√
Ceftriaxone	√		√
Ciprofloxacin					√
Clindamycin		√	√	√
Daptomycin	√		√		√
Doripenem	√				√
Doxycycline		√	√	√
Ertapenem	√		√		√
Gentamicin	√				√
Levofloxacin					√
Linezolid		√
Meropenem	√				√
Metronidazole		√		√
Minocycline		√	√	√
Nafcillin			√	√
Oxacillin			√	√
Piperacillin-tazobactam	√				√
Tigecycline		√	√	√
Tobramycin	√				√
Vancomycin	√				√