Table 1.
Clinical Characteristics of Patients With Septic Shock From the ImmunoSepsis-1 Cohort
| Characteristic | Borderline mHLA-DR (> 30%) Patients (n = 10) | Low mHLA-DR (< 30%) Patients (n = 10) |
|---|---|---|
| Characteristics of patients | ||
| Age, y, median (IQR) | 68 (62–77) | 67 (63–75) |
| Male sex | 5 (50) | 5 (50) |
| Comorbiditiesa (≥ 1) | 2 (20) | 5 (50) |
| SOFA scoreb (day 1), median (IQR) | 9 (8–12) | 11 (10–12) |
| SOFA scoreb (day 3), median (IQR) | 10 (8–11) | 12 (9–14) |
| SAPS IIb (day 1), median (IQR) | 47 (44–54) | 60 (51–73) |
| HLA-DR, % expression on monocytes (days 3–4), median (IQR) | 56 (50–62) | 15 (12–16) |
| Type of admission | ||
| Medical | 7 (70) | 5 (50) |
| Elective surgery | … | 1 (10) |
| Emergency surgery | 3 (30) | 4 (40) |
| Primary site of infection | ||
| Abdominal | 4 (40) | 4 (40) |
| Pulmonary | 4 (40) | 5 (50) |
| Other | 2 (20) | 1 (10) |
| Outcomes | ||
| ICU length of stay, d, median (IQR) | 21 (14–31) | 22 (12–31) |
| Survivors at day 28 | 7 (70) | 4 (40) |
Data are presented as No. (%) unless otherwise indicated.
Abbreviations: HLA-DR, human leukocyte antigen–DR; ICU, intensive care unit; IQR, interquartile range; mHLA-DR, human leukocyte antigen–DR in monocytes; SAPS II, Simplified Acute Physiology Score II; SOFA, Sequential Organ Failure Assessment.
aComorbidities include cardiac, hepatic, respiratory, or/and renal comorbidities.
b SAPS II and SOFA scores were measured after 24 hours of ICU stay (day 1 and day 3).