Table III.

Secondary outcomes

Variable	Day 7 mortality		Length of hospital staya
	(N = 1494)b		(N = 1500)c
	HR (95% CI)	P-value	aHR (95% CI)	P-value
Location infection acquired
Community-acquired (Ref.)	Reference category		Reference category
Nosocomial	0.79 (0.47–1.31)	0.35	0.49 (0.37–0.66)	<0.001
Age (years)
<65	Reference category		Reference category
65–79	3.12 (1.83–5.33)	<0.001	0.80 (0.66–0.97)	0.03
>80	3.99 (2.25–7.08)	<0.001	0.61 (0.48–0.78)	<0.001
Sex (Female)	Reference category		Reference category
Male	1.13 (0.80–1.58)	0.50	093 (0.79–1.09)	0.36
Smoking status (Never)	Reference category		Reference category
Ex-smokers	1.09 (0.78–1.53)	0.61	0.97 (0.82–1.14)	0.70
Current smokers	0.98 (0.49–1.99)	0.96	1.03 (0.76–1.41)	0.83
C-reactive proteind	1.01 (1.005–1.008)	<0.001	0.997 (0.996–0.998)	<0.001
Patients with diabetes	1.00 (0.69–1.44)	0.99	0.94 (0.78–1.13)	0.50
Patients with CAD	1.59 (1.11–2.28)	0.01	1.09 (0.89–1.35)	0.39
Patients with hypertension	0.86 (0.61–1.21)	0.38	0.91 (0.77–1.07)	0.24
Patients with reduced renal function	1.95 (1.39–2.73)	<0.001	0.91 (0.76–1.09)	0.32
Clinical Frailty Scale
1, 2	Reference category		Reference category
3, 4	1.28 (0.65–2.52)	0.48	0.94 (0.77–1.16)	0.58
5, 6	1.86 (0.91–3.79)	0.09	0.73 (0.56–0.96)	0.02
7[en-rule]9	3.62 (1.78–7.34)	<0.001	0.70 (0.53–0.94)	0.02

HR, crude hazard ratio; aHR, adjusted hazard ratio; CI, confidence interval; CAD, coronary artery disease.

^aThe multivariable mixed-effects logistic and cox regressions were adjusted for: age group; sex; smoking; C-reactive protein; diabetes; CAD, coronary artery disease; hypertension; and the Clinical Frailty Scale.

^bSix cases were excluded from the analysis as the patient was followed up for less than 7 days and alive and in hospital.

^cTwenty cases were not included in the analysis due to missing covariate data (see Table I).

^dFitted as a slope parameter.