Table 5.
Series of patients who underwent adjuvant therapy and who experienced relapse of disease.
| Patient | Previous therapies | Surgery | pTNM | PNI/LVI | Adjuvant therapy | Recurrence/Time of relapse (years) | rTNM | Salvage therapy |
|---|---|---|---|---|---|---|---|---|
| 1 | – | Type IIIb glossectomy, SND, forearm free flap | pT2N0M0 | LVI | CHT (Taxit + 63 Gy) |
– | – | – |
| 2 | – | Type IIIb glossectomy, SND, forearm free flap | pT2N2bM0 | LVI | – | Nodal relapse (contralateral lymph node) | rpTxN2cM0 | SND |
| 3 | – | Type IIIb glossectomy, MRND, forearm free flap | pT3N2bM0 | – | CHT (Al Sarraf + 63 Gy) |
Nodal relapse (contralateral lymph node) |
rypTxN3M0 | SND + CHT (Taxit) |
| 4 | – | Type IIIb glossectomy, FND + SND, forearm free flap | pT4aN1M0 | LVI | CHT-RT (Taxit + 63 Gy) | Nodal relapse (contralateral lymph node) |
rypTxN3M0 | RND |
| 5 | – | Type IIIb glossectomy, FND, forearm free flap | pT2N2bM0 | LVI | CHT-RT (CDDP + 63 Gy) | – | – | – |
| 6 | Surgery + RT | Type IVb glossectomy, SND, VRAM free flap | rpT4aN0M0 | – | CHT (Taxit) | Local (floor of mouth) |
rycT4aN0M0 | Palliative CHT |
| 7 | Surgery + RT | Type IIIb glossectomy, marginal mandibulectomy, DCIA free flap | rypT3N0M0 | – | CHT (Taxit) | Local extended to pterygoid space | rycT4bN0M0 | Palliative CHT |
| 8 | – | Type IVa glossectomy, FND + FND, forearm free flap | pT2N2cM0 | – | CHT-RT (Taxit + 63 Gy) | – | – | – |
| 9 | – | Type IIIb glossectomy, SND, forearm free flap | pT3N2bM0 | LVI | CHT-RT (Platin + 60 Gy) | – | – | – |
| 10 | CHT-RT | Type V glossectomy, SND + SND, VRAM free flap | ypT4aN0M0 | PNI-LVI | – | Local (floor of mouth) |
rycT4aN0M0 | CHT |
| 11 | Surgery + RT | Type IIIb glossectomy, SND, forearm free flap | ypT2N0M0 | – | – | Local (floor of mouth) Distant (lung) |
rycT4aN0M1 | Palliative CHT |
| 12 | – | Type V glossectomy, SND + SND, VRAM free flap | pT3N0M0 | – | – | Nodal relapse (homolateral lymph node) | rpT0N2aM0 ENE+ | SND + CHT-RT |
| 13 | – | Type IIIb glossectomy, FND, forearm free flap | pT3N2bM0 | PNI-LVI | CHT-RT (Taxit + 59 Gy) | – | – | – |
| 14 | – | Type IIIb glossectomy, SND, forearm free flap | pT3N1M0 | LVI | – | Local (base of tongue) Distant (lung) |
rcT4aN2cM1 | CHT |
| 15 | – | Type IIIb glossectomy, FND, forearm free flap | pT2N1M0 | LVI | – | Local (floor of mouth) Distant (mediastinum) |
rcT4aN2bM1 | CHT |
| 16 | – | Type IIIb glossectomy, FND, forearm free flap | pT4aN2bM0 | PNI-LVI | CHT-RT (Taxit + 63 Gy) | – | – | – |
| 17 | – | Type IVa glossectomy, FND + FND, forearm free flap | pT4aN3bM1 ENE+ | PNI-LVI | – | Local (tongue) Distant (C1) |
rcT4aN0M1 | Palliative CHT |
| 18 | – | Type IIIb glossectomy, FND, forearm free flap | pT3N2bM0 | PNI-LVI | RT (63 Gy) | Distant (lung, T11, L1) |
rycT0N0M1 | Palliative CHT |
| 19 | – | Type IIIb glossectomy, SND, forearm free flap | pT3N0M0 | PNI | RT (63 Gy) | – | – | – |
| 20 | – | Type IIIb glossectomy, FND, forearm free flap | pT3N2bM0 | PNI-LVI | CHT-RT (Taxit + 63 Gy) | Distant (lung) | rycT0N0M1 | CHT |
| 21 | – | Type IIIb glossectomy, SND + SND, forearm free flap | pT2N0M0 | PNI | RT (54 Gy) | Nodal relapse (contralateral lymph node) |
rypTxN2cM0 | SND |
| 22 | – | Type IIIb glossectomy, FND, forearm free flap | pT2N2bM0 | PNI-LVI | RT (54 Gy) | – | – | – |
| 23 | – | Type IIIb glossectomy, SND, forearm free flap | pT3N1M0 | PNI-LVI | RT (54 Gy) | Distant (supraclavicular fat) | rcT0N0pM1 | MRND |
| 24 | – | Type IIIb glossectomy, SND + SND, forearm free flap | pT4aN0M0 | – | RT (60 Gy) | – | – | – |
| 25 | – | Type IVa glossectomy, FND + SND, forearm free flap | pT4aN2cM0 | – | – | Local (tongue) Distant (lung) |
rcT4aN0M1 | Palliative CHT |
| 26 | – | Type IIIb glossectomy, FND, forearm free flap | pT3N1M0 | PNI | RT (63 Gy) | – | – | – |
| 27 | – | Type IIIb glossectomy, FND, forearm free flap | pT2N2bM0 | PNI-LVI | RT (63 Gy) | – | – | – |
| 28 | CHT (TPF) + CHT-RT (Erbitux) | Total glossectomy, FND + FND, ALT free flap | ypT4aN2cM0 | PNI-LVI | – | Locoregional (tongue, contralateral lymph node) | rycT4aN2cM0 | CHT (CDDP + Erbitux) |
| 29 | – | Total glossectomy, FND + FND, ALT free flap | pT4aN3bM0 ENE+ | PNI-LVI | – | Distant (brain) | rcT0N0M1 | – |
| 30 | Surgery | Type IIIb glossectomy, SND, forearm free flap | (m)pT3N0M0 | PNI | RT (60 Gy) | – | – | – |
| 31 | – | Type IVb glossectomy, FND + SND, ALT free flap | pT3N1M0 | – | RT (63 Gy) | – | – | – |
| 32 | – | Type IVa glossectomy, SND + SND, forearm free flap | pT3N1M0 | PNI | RT (63 Gy) | – | – | – |
Taxit, Taxotere; CDDP, Cisplatinum; Al Sarraf, Cisplatinum + 5-Fluorouracil.