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. Author manuscript; available in PMC: 2020 Jul 21.
Published in final edited form as: Cell Chem Biol. 2018 Dec 27;26(3):400–410.e3. doi: 10.1016/j.chembiol.2018.11.004

Figure 6. Proposed model for the role of Y490 and Y785 in TrkA-mediated PC12 cell differentiation.

Figure 6.

The Raf/MEK/ERK signaling cascade, primarily instigated by Y490 of TrkA, is essential for PC12 cell differentiation. Y785 instigates the PLCγ-PKC pathway, which feeds into the Raf/MEK/ERK signaling cascade. Mutating Y785 or inhibiting the PLCγ-PKC pathway results in diminished receptor-mediated ERK signaling and differentiation in PC12 cells.