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. 2019 Mar 7;29(11):1757–1771. doi: 10.1093/hmg/ddy430

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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HTT CAG repeat length enhances sensitivity to oxidative stress. Live-cell fluorescence intensity-based survival analysis of human NPCs from either an unaffected (17m8 CAG17/17) or HD affected (60i4 CAG60/18) individual. Bar plots showing compound dose (untreated or 1 mm or 5 mm) and HTT CAG repeat length (CAG17 versus CAG60)-dependent impact on cellular homeostasis. For each cell line, at least eight biological replicates/line across two independent experiments were measured. Student’s t-test, ^** indicates P < 0.01 while ^*** indicates P < 0.001.