Table 4.

Selected active clinical trials of hippocampal avoidance-WBRT/PCI in SCLC.

ClinicalTrials.gov Trial ID	Intervention	Primary end point	Study status	Study design
NCT02635009	WBRT ± HA in LS and ES-SCLC	Phase II—Intracranial relapse Phase III—Delayed recall deterioration Status	Active, recruiting	Phase II/III
NCT01780675	PCI ± HA in SCLCI-IV	Neurocognitive decline	Active, not recruiting	Phase III
NCT02906384	PCI ± HA in SCLC	Memory preservation and MRI changes	Active, Recruiting	Phase II

WBRT, whole brain radiation therapy; PCI, prophylactic cranial irradiation; HA, hippocampal avoidance.