Table 5.

Selected active clinical trials of brain SRS in SCLC.

ClinicalTrials.gov Trial ID	Intervention	Primary end point	Study status	Study design
NCT03297788 (ENCEPHALON)	WBRT vs. SRS for 1-10 SCLC-BM	Neurocognition	Active, recruiting	Phase II
NCT02978404	SRS + nivolumab for SCLC-BM	Intracranial PFS	Active, recruiting	Phase II
NCT03391362	SRS for 1–6 SCLC-BM	Death due to progressive neurologic disease	Active, recruiting	Phase II

SRS, stereotactic radiosurgery; BM, brain metastases; PFS, progression-free survival.