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. Author manuscript; available in PMC: 2020 Jul 21.
Published in final edited form as: Drug Metabol Drug Interact. 2011 Nov 18;26(4):169–179. doi: 10.1515/DMDI.2011.027

Figure 1. Gene duplication and fate of duplicated genes in ABC transporters.

Figure 1

The transporter genes ABCG2 and ABCG3 duplicated from an ancestral gene to carry out different specialized functions. ABCB1 and ABCB4 underwent duplication (both located adjacent to each other on the same chromosome) but became specialized to perform distinct functions. ABCG5 and ABCG8 duplicated from the ancestral gene and also became specialized as obligate heterodimers to perform a similar function, while the genes ABCA14-ABCA17 underwent duplication and specialization in certain mammals but were lost in primates.