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. 2020 Jul 20;13:81. doi: 10.1186/s13048-020-00685-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Knockdown of circRNA-UBAP2 (sh-UBAP2) suppressed the malignant biological behavior of ovarian cancer cells. a, Relative expression of circRNA-UBAP2 in OVCAR-3 and ES-2 were reduced after transfected sh-UBAP2 measured by RT-qPCR assay. ^*P < 0.05 vs NC group. b, Proliferation of OVCAR-3 and ES-2 cells were inhibited after transfected sh-UBAP2 measured by CCK-8 assay. ^*P < 0.05 vs NC group. c, Apoptosis of OVCAR-3 and ES-2 cells were promoted after transfected sh-UBAP2 measured by flow cytometry. ^*P < 0.05, ^**P < 0.01 vs NC group. d, Cell cycle of OVCAR-3 and ES-2 cells were influenced after transfected sh-UBAP2 measured by flow cytometry. ^*P < 0.05 vs NC group. e, Apoptosis-related proteins Bcl-2, Bax and caspase-1 of OVCAR-3 and ES-2 cells were upregulated after transfected sh-UBAP2 measured by western blotting. ^*P < 0.05 vs NC group