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. 2020 Jul 20;20:107. doi: 10.1186/s12902-020-00593-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Characterization of differentially expressed lncRNAs in High Glucose (HG) versus Control Normal (CN) cells. a Correlation plots, b volcano plots, and c heatmap of differentially expressed lncRNAs. For panels a and b, blue indicates > 2 fold decreased expression and red indicates > 2 fold increased expression of the dysregulated lncRNAs in HG-induced human umbilical vein endothelial cells (HUVECs) (p < 0.05). The gray indicates no significant change. For panel C, red indicates high expression and green indicates low expression of genes with > 2 fold dysregulation for each of the 6 samples