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. 2020 Jul 20;20:678. doi: 10.1186/s12885-020-07180-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Therapeutic efficacy of CAR-T cells on the xenograft mice model. a The Vivo imaging results of OVCAR3-MUC16-GFP-PDL1-luc tumor-bearing mice before treatment. NPG mice were intraperitoneally injected with OVCAR3-MUC16-GFP-PDL1-luc cells (5 × 10⁵) and 50ul Matrigel for 48 h, followed by measuring via IVIS Spectrum and analyzed by Living Image. b The Vivo imaging results of tumor progression in mice at four points (day 7, day 14, day 21and day 28) in time, and were randomized divided into four groups. The black area and empty spaces indicate the mice have died. c The therapeutic effects of the four T cells are compared at the same point in time. d The therapeutic effect of each T cell group is compared at different points in time. e The survival curve of tumor-bearing mice. All groups below the horizontal line have been compared, the two groups pointed by the arrow line are compared. Data show the mean ± SD, and the results were analyzed with Student’t test. Error bars represent the SD. The survival curve was drawn by GraphPad Prism 8.3.0 software. ns: P > 0.05,*: P < 0.05,**: P < 0.01.