Table 2.
Biomarker for gut barrier dysfunction, inflammation and bacterial translocation, Data are shown as median and 95% confidence interval
| Dementia patients (n = 23) | Controls (n = 18) | p-value | |
|---|---|---|---|
| Serum diaminooxidase (U/ml) | 20.8 (9.7;29) | 11.2 (8.4; 13.8) | 0.025 |
| Fecal zonulin (ng/ml) | 33.8 (31.2; 57) | 55.1 (40.8; 76.7) | n.s |
| C-reactive protein (mg/L) | 5 (4; 11) | 2 (1.2;3.4) | n.s |
| Serum lipopolysaccharide binding protein (μg/ml) | 17.9 (16.1; 18.6) | 20.0 (14.6; 21.3) | n.s |
| Soluble CD 14 (μg/ml) | 2.4 (1.9; 3.1) | 1.8 (1.7; 2.1) | 0.022 |
| Fecal calprotectin (ng/ml) | 31.5 (26.6; 85.8) | 49.0 (18.2; 66.3) | n.s |
| Endotoxin (EU/ml) | 0.26 (0.0; 0.33) | 0.25 (0.09; 0.53) | n.s |
| Peptidoglycana (ng/mL) | 0.96 (0.26; 1.66) | 0.42 (0.30;1.05) | n.s. |
| Bacterial DNA (μM) | 0.06 (0.00;1.46) | 0.7 (0.0; 1.29) | n.s |
apeptidoglycan was only measurable in 12% of the samples, therefore median and confidence interval only for the positive samples are shown. CD cluster of differentiation, EU endotoxin units