Table 3.

Multivariate RDA to identify the most important explanatory variables for microbiome composition changes

Variable	Control versus Dementia	Severity of dementia
BMI	Variance = 33.18	Variance = 33.18
	F = 1.29	F = 1.29
	P = 0.006	P = 0.008
Total protein	Variance = 29.19	Variance = 29.19
	F = 1.14	F = 1.14
	P = 0.067	P = 0.070
soluble CD14	Variance = 29.06	Variance = 29.06
	F = 1.13	F = 1.13
	P = 0.072	P = 0.079
Statins	Variance = 32.06	Variance = 32.06
	F = 1.25	F = 1.25
	P = 0.009	P = 0.014
Clock-drawing test	Variance = 25.89	Variance = 25.89
	F = 1.01	F = 1.01
	P = 0.376	P = 0.374
Age	Variance = 25.88	Variance = 25.88
	F = 1.01	F = 1.01
	P = 0.427	P = 0.409
Sex	Variance = 27.63	Variance = 27.63
	F = 1.08	F = 1.08
	P = 0.137	P = 0.154
NSAIDS	Variance = 28.17	Variance = 28.17
	F = 1.10	F = 1.10
	P = 0.098	P = 0.107

BMI body mass index, NSAIDS non-steroidal anti-inflammatory drugs