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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Am J Transplant. 2019 Dec 27;20(4):977–987. doi: 10.1111/ajt.15739

FIGURE 5.

FIGURE 5

Phenotype of B cells from naive and long-term graft survivor (LTS) OBI mice. A, Surface staining of B cells from naive and LTS OBI mice show similar levels of TIM1 and CD5 and higher levels of CD40. B, Tolerant OBI B cells show an increased proportion of LAP+ (a marker for TGF-β production) B cells upon stimulation with LPS, PMA, and ionomycin. C, Tolerant OBI B cells, however, do not show upregulation of IL-10 under the same stimulation protocol. Data are representative of 3 experiments. ns, nonsignificant. *P < .05. LPS, lipopolysaccharide; MFI, median flourescence intensity; OBI, ovalbumin (OVA)-specific BCR mice; PMA, phorbol myristate acetate; TGF, transforming growth factor