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. 2020 Jul 14;14:646. doi: 10.3389/fnins.2020.00646

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Copyright © 2020 Ma, Fu, Cao, Shao, Song, Sheng, Yang, Cui, Chen, Zhao, Luo, Lai and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The influence of the inactivation of the CA1 of dorsal hippocampus on the CPA score and on conditioned context-induced increase in the expression of c-Fos in BLA in morphine withdrawn mice. (A) The experimental timeline and groups for the CPA procedure. (B) The influence of the inactivation of the CA1 of dorsal hippocampus on the CPA score in morphine withdrawn mice. Left panel: the typical injection site of muscimol in the CA1 of dorsal hippocampus. Scale bar = 500 μm. Right panel: the CPA score of each group (n = 10 in saline + saline + muscimol group, n = 7 in morphine + naloxone + muscimol group, n = 5 in morphine + naloxone + saline group, *p = 0.0003, compared with pre-test, two-way ANOVA, Bonferroni post hoc analysis). (C) The influence of the inactivation of the CA1 of dorsal hippocampus on conditioned context-induced increase in the expression of c-Fos in BLA in morphine withdrawn mice. Left panel: C-Fos positive neurons of the BLA in each group. Bar = 100 μm. Higher magnification images of boxed regions are shown on the left. Scale bar = 20 μm. Right panel: the average number of c-Fos positive neuron of the BLA in each group (n = 4 in saline + saline + muscimol group, n = 6 in morphine + naloxone + muscimol group, n = 4 in morphine + naloxone + saline group, *p = 0.001, one-way ANOVA following by Tukey post hoc analysis) Data are shown as the mean ± SEM.