Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 14;14:646. doi: 10.3389/fnins.2020.00646

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Ma, Fu, Cao, Shao, Song, Sheng, Yang, Cui, Chen, Zhao, Luo, Lai and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The indirect connection from the CA1 of dorsal hippocampus to the BLA in mice of control group and the change in the indirect projection from the CA1 of dorsal hippocampus to the BLA in mice with conditioned place aversion. (A) Left panel: the experimental timeline and groups for the CPA procedure. Right panel:diagram of the injection site of H129-G4 in the CA1 of dorsal hippocampus. (B) Left panel: the typical injection site of H129-G4 (green-colored) in the CA1 of dorsal hippocampus. Scale bar = 500 μm. Right panel: the CPA score of each group (n = 5 in saline + saline group, morphine + saline group and morphine + naloxone group, n = 6 in saline + naloxone group, *p < 0.0001, compared with pre-test, two-way ANOVA, Bonferroni post hoc analysis). (C) Left panel: H129-G4 positive neurons (green-colored) in the BLA in each group. Scale bar = 100 μm. Right panel: the density of H129-G4 positive neurons in the BLA in each group (n = 5 in saline + saline group and morphine + naloxone group, n = 3 in saline + naloxone and morphine + saline groups, *p < 0.0001, compare to saline + saline group, saline + naloxone group and morphine + saline group, one-way ANOVA following by Tukey post hoc analysis). (D) Left panel: H129-G4 positive neurons (green-colored) in the POR in each group. Scale bar = 100 μm. Right panel: the density of H129-G4 positive neurons in the POR in each group (n = 3 in saline + saline group and saline + naloxone group, n = 4 in morphine + saline group and morphine + naloxone group, *p < 0.0001, compare to saline + saline group, saline + naloxone group and morphine + saline group, one-way ANOVA following by Tukey post hoc analysis). Data are shown as the mean ± SEM.