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. 2020 Jul 21;32(3):107920. doi: 10.1016/j.celrep.2020.107920

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© 2020 The Authors

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Microneutralization Assay with Panel of WT Lyssaviruses

(A and B) Neutralizing antibody 50% endpoint titers in sera from mice 47 days after first immunization with rRABV (blue/white), rRABV with the adjuvant GLA-SE (blue/gray), LyssaVax (purple/white), or LyssaVax with GLA-SE (purple/gray) (n = 10 mice per group, analyzed in duplicate, mean ± SD). See Figure 3A for immunization scheme. Lyssaviruses tested span two phylogroups: (A) RABV, EBLV-1, DUVV, and IRKV; and (B) MOKV, LBV-D, LBV-D, and SHIBV. All titers normalized to day 0 sera were pooled within groups. Upper limit endpoint: 2,795. Microneutralizations were analyzed using an ordinary one-way ANOVA test with Tukey’s multiple comparisons (^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001 for adjusted p values; n.s. is not significant).