Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 14;11:755. doi: 10.3389/fphys.2020.00755

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Kitada, Xu, Ogura, Monno and Koya.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Mitochondrial oxidative, manganese superoxide dismutase (Mn-SOD) dysfunction, and kidney disease. Mitochondrial oxidative stress associated with Mn-SOD dysfunction in the kidney is one of the key factors underlying the pathogenesis of kidney disease, including acute kidney injury (AKI), chronic kidney disease (CKD), as well as the AKI to CKD transition through glomerular and tubulointerstitial fibrosis, inflammation, excessive apoptosis of renal cells, and tubular cell damage. Several mitochondria-targeted drugs may improve the kidney disease through the improvement of mitochondrial oxidative stress. I/R, Ischemia/reperfusion; DKD, diabetic kidney disease; HT, hypertension; UUO, unilateral ureteral obstruction.