Table 2:

Approximate Population-Attributable Risk Estimates for Genetic Disorders and Incidence in African Americans

Genetic Variant	Population Prevalence	ESKD Population Attributable Risk %
APOL1 High Risk ESKD in general population26	13%	19%
Diabetic Kidney Disease27	15%	13%
High Risk APOL1 and Biopsy-proven FSGS-ESKD18	13%	67%
High Risk APOL1 and Biopsy-proven Hypertensive ESKD9	13%	45%
High Risk APOL1 and HIVAN-ESKD	13%	78.4%
Sickle Cell Trait12	8%	9.9%
NPHS1 T233A58	-	1.1%
NPHS1 Y1174H (protection)58	-	2.43%
NPHS1 H800R (protection)58	-	4.56%

^*Population Attributable Risk (PAR) percent calculated: PAR= P_e (RR_e −1)/1+ P_e (RR_e −1) ×100,^97,98 where P_e is the prevalence of the exposure and RR_e is the relative risk of disease due to that exposure.